Schematic of point mutations in the Abl kinase domain.

The Abl kinase domain, from amino acid 240 to 500, is shown with the ATP binding domain (P), the catalytic domain (C) and the activation loop (A). The numbers below the kinase domain are amino acids that are mutated in patients who relapsed on therapy with imatinib. The vertical lines above the kinase domain indicate the number of times each amino acid has been found to be mutated as compiled from Shah et al,⁴³ Hochhaus et al,⁴² Branford et al,⁴⁴ von Bubnoff et al,⁴⁵ and Hofmann et al.⁴⁷ Adapted from Shah et al.⁴³