Figure 4.
Regulation of osteoclast formation in myeloma.
Marrow stromal cells bind myeloma cells and induce production of IL-6, RANK ligand, and TNF-α. In addition, myeloma cells produce MIP-1α, IL-1, and TNF-α, which can induce osteoclastogenesis.
Regulation of osteoclast formation in myeloma.
Marrow stromal cells bind myeloma cells and induce production of IL-6, RANK ligand, and TNF-α. In addition, myeloma cells produce MIP-1α, IL-1, and TNF-α, which can induce osteoclastogenesis.
