Figure 1.
Hypothetical graph showing the kinetics of leukemic cell decrease and re-growth in several ALL patients during and after treatment with the I-BFM-SG treatment protocol.
MRD curves represent individual patients of the three MRD-based risk groupstwo patients with slow MRD clearance (high-risk group), two patients with moderate MRD clearance (intermediate-risk group), and one patient with rapid MRD clearance (low-risk group).30 The detection limit of cytomorphologic techniques as well as the detection limit of flow cytometric immunophenotyping and PCR techniques are indicated. I: induction treatment; C: consolidation treatment; II: re-induction treatment.
