Emanuel Figure 3 (in Arceci et al). Schema of GM-CSF signal transduction through the Ras signaling pathways. Potential inhibitors of this pathway are depicted in orange. E21R is a GM-CSF antagonist analogue. DT388-GM-CSF is a GM-CSF molecule/diphtheria toxin fusion construct. / Abbreviations: GM-CSF, granulocyte-macrophage colony-stimulating factor; FTIs, farnesyltransferase inhibitors; GTP, guanosine triphosphate; GDP, guanosine diphosphate; PI 3-K, phosphatidylinositol 3-kinase; PKB, protein kinase B; MEK, mitogen-activated protein kinase kinase.

Emanuel Figure 3 (in Arceci et al). Schema of GM-CSF signal transduction through the Ras signaling pathways. Potential inhibitors of this pathway are depicted in orange. E21R is a GM-CSF antagonist analogue. DT388-GM-CSF is a GM-CSF molecule/diphtheria toxin fusion construct.

Abbreviations: GM-CSF, granulocyte-macrophage colony-stimulating factor; FTIs, farnesyltransferase inhibitors; GTP, guanosine triphosphate; GDP, guanosine diphosphate; PI 3-K, phosphatidylinositol 3-kinase; PKB, protein kinase B; MEK, mitogen-activated protein kinase kinase.

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