Alteration in the polysomal distribution of γ-globin mRNA in reticulocytes as a result of butyrate therapy.

Analysis of γ-globin mRNA from reticulocytes from a representative butyrate responsive sickle cell disease patients (⧫) Before therapy; (▪) 24 hours after therapy. Fractions 1 and 2 are the pre-polysomal region. Fractions 5 to 8 represent the 1 to 3 ribosomal region.