Figure 2.
Figure 2. Characteristics of the most common and the most unique B-cell chronic lymphocytic leukemia (B-CLL) B-cell receptors (BCRs). / The prototypic unmutated BCR is represented by the rearrangement that uses the VH 1-69 gene, whereas the prototypic mutated BCR is represented by the VH3-07 rearrangement. The VH4-34 rearrangements have characteristics of both the prototypic unmutated and mutated BCRs. The arrangements involving these 3 VH genes are the most common in B-CLL. Less common but remarkably unique BCRs are represented by the VH4-39 and VH3-21 rearrangements that pair with defined D, JH, VL, and JL genes. These latter BCRs are the most striking examples of antigen selection of a specific antigen-binding site. Adapted, with permission, from the Annual Review of Immunology, Volume 21, 20032 (www.annualreviews.org). / Abbreviations: BCR, B-cell receptor; B-CLL, B-cell chronic lymphocytic leukemia; CDR, complementarity determining region.

Characteristics of the most common and the most unique B-cell chronic lymphocytic leukemia (B-CLL) B-cell receptors (BCRs).

The prototypic unmutated BCR is represented by the rearrangement that uses the VH1-69 gene, whereas the prototypic mutated BCR is represented by the VH3-07 rearrangement. The VH4-34 rearrangements have characteristics of both the prototypic unmutated and mutated BCRs. The arrangements involving these 3 VH genes are the most common in B-CLL. Less common but remarkably unique BCRs are represented by the VH4-39 and VH3-21 rearrangements that pair with defined D, JH, VL, and JL genes. These latter BCRs are the most striking examples of antigen selection of a specific antigen-binding site. Adapted, with permission, from the Annual Review of Immunology, Volume 21, 20032 (www.annualreviews.org).

Abbreviations: BCR, B-cell receptor; B-CLL, B-cell chronic lymphocytic leukemia; CDR, complementarity determining region.

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