Fig. 7.
![Fig. 7. CB2 receptors accounted for the CP 55,940-increased B-cell proliferation. The CB1 receptor antagonist SR 141716 (▪) and the CB2 receptor antagonist SR 144528 (•) were preincubated at indicated concentrations for 30 minutes with purified tonsillar B cells before the addition of 10 nmol/L CP 55,940. B cells were induced to proliferate for 72 hours after ligation of CD40 antigen. Data are expressed taking as 100% the difference between [3H] thymidine uptakes (which corresponded to 15,200 cpm) into B cells activated with CD40 MoAbs with and without 10 nmol/L CP 55,940. *P ≤ .05.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/92/10/10.1182_blood.v92.10.3605/4/blod42205007x.jpeg?Expires=1736074835&Signature=oY84s6BHFFxZJNVsnyaFq~iiz7JYWFvtcsxs2rOxRhad060kK3lyURQF6XnD1S0Rl~~qrqpbDDxLWsjPp4v-ZB6mAtmlHzD4Wyw7nubjIumWhiOkE-K2zBwTLJTCkQPi5Jf5sFMaUcAKLdRvlOmT7lc9CbiJINaeMKRGplOxFFxE45GnFwuJiDNAvmIMF19EUA3aHAEw4IZHFlo9WiRN0~lvG9Ahl3YV3rKH9QT6zxi4hdEpB6qFukY17nlqlsmo7tRTnJTnqm0nPvsk~AxL~sqgG5OCoO85Rqzd6E6SMIz37J9d~Ch4p4zR3dQRRsB-zPVlwVjOVrzLq-AUnJXTCg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
CB2 receptors accounted for the CP 55,940-increased B-cell proliferation. The CB1 receptor antagonist SR 141716 (▪) and the CB2 receptor antagonist SR 144528 (•) were preincubated at indicated concentrations for 30 minutes with purified tonsillar B cells before the addition of 10 nmol/L CP 55,940. B cells were induced to proliferate for 72 hours after ligation of CD40 antigen. Data are expressed taking as 100% the difference between [3H] thymidine uptakes (which corresponded to 15,200 cpm) into B cells activated with CD40 MoAbs with and without 10 nmol/L CP 55,940. *P ≤ .05.
