Effect of a single bolus infusion (0.4 g/kg) of IVIg on IgG, IgG2, IgA, and IgM production in PBMC cultures from 8 patients with HIV infection. PBMCs were prepared from blood samples taken at the indicated time points before and after IVIg infusion and cultured without stimulation (left panels) or stimulated with anti-CD40 monoclonal antibody (right panels). Supernatants were harvested after 7 days and assayed for Igs by ELISA. Data are given as medians and 25th and 75th percentiles. *P < .05 versus levels before infusion (0 hours).