Clones TcR γ junctional sequences in patients no. 1, 3, and 4. (A) The sequences, the Vγ segments involved, and the clone-specific antijunctional oligonucleotides (AJO) are shown. N, N regions. (B) Hybridization experiments using patient-specific AJO probes. (1) Patient no. 1; (a) jejunum; (b) accessory spleen; (c) mesenteric lymph nodes. (3) Patient no. 3; (a) duodenal biopsy; (b through f) postmortem samples obtained 30 months later. (b) Small bowel; (c) sigmoid colon; (d) colon; (e) thoracic lymph nodes; (f) mesenteric lymph nodes. (4) Patient no. 4; (a) duodenal biopsy; (b) jejunal biopsy 30 days later; (c) peripheral blood specimen obtained 64 days later at the time of overt lymphoma. PC, polyclonal controls.