Reduction in MLR response in transplant recipients via induction of oral tolerance toward recipient's splenocytes.

Induction of tolerance in recipient BALB/c mice toward the recipient splenocytes was measured using the MLR test. Responding tolerated BALB/c mice transplanted with B10.D2 splenocytes and fed with BALB/c splenocyte homogenates after transplantation, were tested versus BALB/c, showed marked reduction in the MLR response (A). In contrast, nontolerant control BALB/c mice fed with B10.D2 splenocyte homogenates, tested versus similar BALB/c targets showed marked MLR response (B,P < .005). Similarly, nontolerant control BALB/c mice splenocytes fed with BSA, tested versus similar BALB/c targets showed marked MLR response (C, P < .005).