Effect of toleration on histologic evaluation of liver in transplants recipients.

Liver biopsies were performed on splenocyte recipients 52 days after transplantation. Mice in experimental group A, fed after transplantation with homogenates of splenocytes derived from recipient strain BALB/c mice showed mild degree of portal inflammation (Panel A). In contrast, biopsies from control nontolerant recipients in groups B and C, fed after transplantation with homogenates prepared from B10.D2 mouse splenocytes or BSA, respectively, showed portal and bile duct inflammation (Panels B and C). (HαE, original magnification ×40.)