Secondary structure of the L-ferritin IRE.

The yellow area marks conserved features of the IRE consensus based on the IRE sequences of all known ferritin and transferrin receptor mRNAs. Positions of the point mutations responsible for hereditary hyperferritinemia/cataract syndrome are shown, with the arrow indicating the observed nucleotide substitution. In addition, the following deletions have been described: C10-A38,64A38-C39, and U42-G57.71 Adapted from Allerson et al.75