Endostatin-induced apoptosis is dependent on the adaptor molecule Shb.

IBE infected with vector-containing retrovirus (A) or retrovirus encoding Shb (B) or an Shb SH2-domain mutant R522K (C) were analyzed with regard to proportion of Annexin V-stained cells by flow cytometry. * denotes P < .05 when tested against FGF-2 alone using a paired Student t test.