SDF-1 is a more potent chemoattractant for immature CFCs than MIP-1.

(A) Spontaneous migration of CFCs (CTRL) and migration toward SDF-1 or MIP-1α in a transwell assay. (B) Adhesion of CD34⁺ cells to BSA (CTRL) or FN- coated wells and FN with SDF-1 or MIP-1α. (C) Quantification of CFC levels in the adherent CD34⁺ cell populations. (D) Percent inhibition of CD34⁺ cell adhesion to FN, by antibodies to VLA-4 or VLA-5, in the presence or absence of SDF-1 and MIP-1α. The results shown represent the average of 3 different experiments plus or minus SE. (*Indicates P < .05).