Reduced numbers of CFU-GM precursors in the BM of flt3L−/− mice.

BM cells were cultured in methylcellulose in the presence of rmu IL-3 plus rmu KL plus rhu EPO (see “Materials and methods”). (A) Frequency of clonal CFU-GM progenitors. (B) Absolute number of CFU-GM per 2 femurs (n = 16 mice). Data were pooled from 4 experiments and are presented as the mean ± SD. *P = .0012.