Genomic landscape of somatic mutations, gene fusions, and copy number variations in leukemia. Dark blue dots represent somatic mutation with VAFs. Light blue lines represent fusion genes. Dark bars represent copy number variations. (A) In pretransplant leukemia, WGS and RNA-seq identified 270 somatic mutations (251 mutations in protein-coding genes, 16 in intergenic regions, and 3 in noncoding RNA), 16 fusion genes, and 725 gene loci with copy number variations. (B) Posttransplant leukemia harbors 312 somatic mutations (296 in protein coding genes, 19 in intergenic regions, and 6 in noncoding RNA), 13 fusion genes, and 332 gene loci with copy number variations.