Immunologic impact of low-dose IL-2 on lymphocytes. (A) CD4Treg/Tcon ratio for the pediatric and adult cohorts. (B) Fold change in absolute CD8 T-cell and NK cell counts for the pediatric and adult cohorts. (C) Recent thymic emigrant (RTE) CD4Tregs shown as a percentage of the naive CD4Treg population for the pediatric and adult cohorts. Median values (circles) and the IQR (whisker bars) are shown at each time point. The number of patients evaluated at each time point is indicated at the bottom. *P < .05 pediatric vs adult, Wilcoxon rank-sum test.