Arithmetic mean thrombin generation vs time following andexanet alfa/placebo administration. Rivaroxaban studies (A, cohorts 1-3, upper left panel; cohorts 4-5, upper right panel); edoxaban studies (B, cohorts 1-2, lower left panel; cohort 3, lower right panel). Shaded regions represent day 1 pre-anticoagulant (mean ± 1 standard deviation [light shading]; ± 2 standard deviation [dark shading]) values. rfu, relative fluorescence unit.