Death receptor expression varies across genetic subtypes of B-cell malignancies. (A) Expression of TNFRSF10B across B-cell malignancies in data from the Hemap resource containing aggregated transcriptomic profiles across hematological malignancies. (B) Expression of TNFRSF10B across B-ALL subtypes in data by Gu et al.40 (C) Genetic alterations most significantly associated with TNFRSF10B expression (log2 expression shown as bar plot) in Chapuy et al.41 DLBCL data shown as an oncoprint. FDR for the significance of Spearman correlations between TNFRSF10B expression and alterations are shown. ABC, activated B cell; BL, Burkitt lymphoma; CLL, chronic lymphocytic leukemia; FL, follicular lymphoma; GCB, germinal center B cell; HCL, hairy cell leukemia; IPI, International Prognostic Index; MALT, mucosa-associated lymphoid tissue lymphoma; MCL, mantle cell lymphoma; MZL, marginal zone lymphoma.