Treatment with hPF4 or hPF4 plus KKO or DG-KKO in WT mice undergoing CLP injury. CLP injuries were done as in Figure 5, but with WT mice that either received vehicle, hPF4 at either 20 or 40 mg/kg, or combination therapy of hPF4 (20 mg/kg) plus either 5 mg/kg KKO or DG-KKO. N = 10 animals per arm. (A) Relative platelet counts as in Figure 5A. (B-C) The same as in Figure 5C-D, respectively. (D) MSS in these studies for up to 48 hours after the injury. Mean ± 1 SD shown. (A-D) Statistical analysis was performed with Sidak’s multiple comparison t test.