Loss of SAP-Fyn signaling pathway does not greatly alter AITL-like disease. (A) Abrogation of downstream signaling between SAP and Fyn kinase does not prevent tumor incidence, but may have a partial effect (n = 17 Roquin^san/+; Sh2d1a^+/y and n = 29 Roquin^san/+; Sh2d1a^R78A/y). (B-E) Tumors from Roquin^san/+; Sh2d1a^+/y or Roquin^san/+; Sh2d1a^R78A/y show comparable T-B-cell expression patterns and frequencies (n = 3 Roquin^san/+; Sh2d1a^+/y tumors and n = 7 from Roquin^san/+; Sh2d1a^R78A/y tumors). Error bars in panels B-E represent the SEM. Data are pooled from at least 2 independent experiments. **P < .01.