Figure 4.
Quantitative real-time PCR analysis. This analysis of Tet2 (A) and Tet3 (B) transcript levels in leukemic BM cells from T2ΔT3 (n = 7), ΔT2T3 (n = 4), and ΔT2ΔT3 (n = 7) mice and in whole BM cells from Mx1-Cre–Tet2f/fTet3f/w, Tet2f/wTet3f/f, or Tet2f/fTet3f/f mice (Control; n = 4). The results are normalized to 18S ribosomal RNA and shown relative to the levels seen in the control samples. The samples with presence of residual Tet3 (exon 7-8 region) transcript is denoted within parentheses (#47 and #60). **P < .01, ****P < .0001.

Quantitative real-time PCR analysis. This analysis of Tet2 (A) and Tet3 (B) transcript levels in leukemic BM cells from T2ΔT3 (n = 7), ΔT2T3 (n = 4), and ΔT2ΔT3 (n = 7) mice and in whole BM cells from Mx1-Cre–Tet2f/fTet3f/w, Tet2f/wTet3f/f, or Tet2f/fTet3f/f mice (Control; n = 4). The results are normalized to 18S ribosomal RNA and shown relative to the levels seen in the control samples. The samples with presence of residual Tet3 (exon 7-8 region) transcript is denoted within parentheses (#47 and #60). **P < .01, ****P < .0001.

Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal