Genomic makeup of RRMM. (A) Oncoplot columns showing genomic alterations for the patients in the study: cytogenetic events are in red in the top part (absence of information [NA] in white). Mutations are in the bottom part, color-coded by type. Subclonal mutations have a yellow square in the middle, and biallelic instances of mutations or deletions are outlined in black. (B) Circos plots summarizing the genomic makeup of each patient. Genomic coordinates on chromosomes are on the outer ring; then, working inward, copy number (CN) status (green, deletion or loss; red, amplification or gain), mutations (variants), and interchromosomal rearrangements. (C) Bar chart of the most commonly mutated pathways in the cohort. MAPK_pathway: KRAS, NRAS, BRAF, and FGFR3 mutations; NF-κB pathway: CYLD, BIRC2, BIR3, TRAF2, TRAF3, NFKBIA, and NFKBIE mutations and/or deletions; CRBN pathway: IKZF1 and IKZF3 mutations and CRBN, RBX1, DDB1, and CUL4B mutations and/or deletions; proteasome subunit: mutations in proteasome subunit genes; and TP53 pathway: TP53, ATM, and ATR mutations and/or deletions. (D) Breakdown of the patients based on the presence or absence of high-risk features; left-most bar, % contribution of each feature. (E) Frequency of mutations according to the last line of treatment.