Somatic mutations detected pre-ASCT. Results of targeted deep sequencing of case (red) and control subjects (blue). (A) Total number of mutations according to gene in case and control subjects. (B) Frequency of patients testing positive for one or more mutation(s) in each age group. (C) NGS analysis of the mutational profile of patient 1185 at time points ASCT and tMN diagnosis. N, total number of patients in each age group.