JNJ-67571244 mediates cytotoxicity of AML blasts from primary patient samples. (A) Ex vivo assessment of JNJ-67571244–mediated cytotoxicity of CD33⁺ blasts in fresh AML patient whole blood after 48 hours. Individual EC₅₀ values are shown for each patient sample. (B) Same as panel A but here T-cell activation (CD25 upregulation on CD3⁺ T cells) was measured.