JNJ-67571244 mediates reduction of CD33⁺leukocytes in cynomolgus monkeys. Cynomolgus monkeys were treated with a single IV dose of control (vehicle), 0.05, 0.2, or 1 mg/kg of JNJ-67571244. (A) JNJ-67571244 concentration over time profiles. (B) T-cell activation (% CD25⁺ on CD8⁺ T cells) in peripheral blood. (C) The effect of JNJ-67571244 on granulocytes (neutrophils). (D) The effect of JNJ-67571244 on monocytes.