Venn diagrams showing the number of shared and distinct subclones across disease events. Diagrams were generated by comparing the VDJ sequences of subclones in each disease event of a patient (Table 1) to identify the number of shared and unshared subclones. The numbers in the overlaps represent the number of shared subclones between disease events, whereas the numbers outside the overlap represent the number of unique subclones present for the particular disease event. Values in brackets represent the number of subclones as a percentage of the total number of subclones identified across all disease events. These values were rounded to 1 decimal point. For patient 3, the transformation sample was omitted from analysis because of the difference in CDR3 length in comparison with the first and second relapse. FL, FL diagnosis; FL1, first relapse; FL2, second relapse; FL3, third relapse; tFL1, relapsed tFL.