Association of NT5C2 mutations with recurrent genetic alterations in relapsed BCP-ALL. (A) Distribution of recurrent genetic alterations in relapses with wild-type NT5C2 in comparison with relapses with NT5C2 mutation. Bars represent the percentage of relapses with a given genetic alteration within each category. P values below the .05 level of significance are depicted in bold. (B) Distribution of recurrent genetic alterations in relapses with clonal and with subclonal NT5C2 mutations only in comparison with relapses with wild-type NT5C2. Colored bars (yellow and blue) and black dots highlight the presence of a given genetic alterations in a relapse sample, whereas white bars indicate cases with no data. del, deletion; mut, mutation; rearr, rearrangement; sub, subclonal NT5C2 mutation; wt, wild-type. B-other* represents BCP-ALL relapses lacking the established cytogenetic abnormalities listed below.