SCS reveals heterogeneous clonal evolution in AML. Fishplots illustrating the diversity in clonal evolution captured by SCS at diagnosis, remission, and relapse. Selected cases from patients who relapsed (A-F) and from patients who remained in remission (G-H). For each remission sample, the total number of cells identified as the dominant clone at relapse (or at diagnosis for SU564 and SU290) are indicated in the box. Stacked bar graphs are displayed on the right to illustrate cell frequencies at the respective time points.