HSPC subsets and HSPC heterogeneity. Ternary plots for each patient, showing the K-means cluster analysis of highly active ISs and highlighting the presence of 4 to 6 predominant cell type compositions (HSPC subsets). The lineage output inferred for each IS clone is projected onto a triangle that combines the 5 cell lineages and 3 axis: GM/T/BK (with the proportion of granulocytes and monocytes on the left axis, the proportion of T cells on the right axis, and the proportion of B+NK cells on the bottom axis). The corrected relative abundance of each clone at a specific position is indicated by the dot density. The total number of IS clones at a specific position is indicated by the dot size. The clusters are named according to their centroid (shown in supplemental Figure 14), using the closest reference composition (according to the minimum Kullback-Leibler distance to the 31 reference compositions; supplemental Methods). The proportions of IS in each cluster related to the total number of IS clones are indicated.