Pharmacokinetic-pharmacodynamic relationship curves at trough sampling times. For dabigatran PK and dTT (A, overall; B, aged 12 to <18 years; C, aged 2 to <12 years; D, aged from >3 months to <2 years), aPTT (E, overall; F, aged 12 to <18 years; G, aged 2 to <12 years; H, aged from >3 months to <2 years), and ECT (I, overall; J, aged 12 to <18 years; K, aged 2 to <12 years; L, aged from >3 months to <2 years) by age group. aPTT, activated partial thrombin time; Dabititrn, dabigatran titration; EEOT, early end of treatment; UNS, unscheduled.