Plots showing the time course of SPTCL and HLH episodes in the patient during the past 24 months and the different therapeutic strategies implemented. Clinical findings depict the presence of high fever (red arrows), lymphadenopathies (Lymphad.; +), and pain (+), as well as the presence (+) or absence (−) of panniculitis, detectable either clinically (Clinical) or by PET-CT scan (PET). Dotted lines indicate the lower (lymphocyte count) or the higher (ferritin and LDH serum levels) normal limits. Anakinra was administrated at 100 mg per day, cyclosporine 4 to 6 mg/kg per day, prednisone at 0.5 mg/kg every day, and ruxolitinib first at 15 mg twice daily, then 20 mg twice daily at relapse. N.D., not determined.