Clinical heterogeneity of patients with advSM. Clinical, morphological, and laboratory characteristics (including C findings) of 20 patients with advSM. ¹Anemia (red), transfusion-dependent anemia (brown). ²Numbers in red boxes reflect weight loss in kilograms. ³Splenomegaly includes patients in which splenomegaly would qualify as a B finding and patients with hypersplenism (eg, thrombocytopenia), which would qualify as a C finding. A clear distinction can be challenging in individual patients. ⁴Tryptase >100 ng/mL (red), >1000 ng/mL (brown). ALT, alanine aminotransferase; AST, aspartate aminotransferase; CRP, C-reactive protein; GGT, gamma-glutamyl transferase; GI, gastrointestinal; Hb, hemoglobin; INR, international normalized ratio.