Mutational profiles of HMA + VEN, HMA, and IC (age >65 years) cohorts. HMA + VEN (A), HMA (B), and IC (C) cohorts harbored diverse mutational profiles with a median of 4 mutations per patient, including NPM1⁺. Commonly cooccurring mutations in the context of NPM1 mutations included FLT3-ITD, DNTM3A, IDH1, and IDH2. TET2 mutations were common in the HMA + VEN and HMA cohorts, likely reflective of the older age and the known association with DTA mutations.