Progression of eGFR-CysC. The rate of eGFR-CysC decline in children (A) and adults (B) based on presence or absence of albuminuria. Red lines represent participants with albuminuria, and blue lines represent participants without albuminuria. Filled circles represent mean eGFR value spanned by standard error of the mean. The median yearly eGFR decline (mL/min/1.73 m2 per year) is indicated for both groups. Association between change in eGFR-CysC and ACR as a continuous variable among adult participants with PA (C) and non-PA (D). Regression lines with 95% CIs are shown in red for adults with PA and black for adults with non-PA. (E) Linear regression of eGFR-CysC vs age in children (<18 years). (F) Linear regression of eGFR-CysC vs age in adults.