CD3⁺ T-cell homeostasis at different ages in patients with pDGS and controls. (A) CD3 absolute counts from pDGS patients in the first year of life. The gray boxes indicate the normal age-related ranges for absolute T-cell counts. Most of the values were below the 5th percentile levels for age-matched control samples. No variation in the number of the CD3⁺ T cells was observed during the first year of life. (B) Percentage of patients showing, at different ages, CD3 absolute counts (blue bars) or CD3% (red bars) below the 5th percentile levels for age-matched controls. Apart from the first 3 months of life, CD3% was always more affected than CD3 absolute count. The number of patients with low CD3 count reduced with age, from 92% to 37% (P < .0001). As for the number of patients with low CD3%, it increased between 0 and 1 year and then reduced from 85% to 54% (P < .0001) between 1 and 20 years. (C) CD3 T cells are lower in patients at all ages than in controls but have a slower rate of decline than controls. The gray boxes indicate the normal age-related ranges for absolute T-cell counts.