Clonal cytogenetic evolution. Results from all 83 patients treated with EPAG on both study 1 and study 2. Patients are grouped according to presence or absence of chr7 abnormalities. Timing of cytogenetic evolution is shown in relation to initial treatment with IST as well as EPAG treatment. Further details are given in supplemental Table 5. Cytogenetic evaluations after initial clonal progression were performed off-study and in some cases not at the study site. HSCT, hematopoietic stem cell transplantation.