Longitudinal follow-up of mutated clone size in responding patients on and off EPAG. Candidate gene mutations were analyzed at baseline, primary end point, the longest time point on continuous EPAG, and the longest time point after EPAG was discontinued for robust response in 12 responding patients. Each panel shows the results in a single patient, with mutated clone size off EPAG (at baseline and at longest follow-up time point off EPAG after robust response) designated by open symbols, and clone size on EPAG (at primary end point and at longest follow-up on EPAG) designated by closed symbols. Specific mutations are listed in supplemental Table 8.