Gene subset regulated by CDK6 silencing not by kinase inhibition in BV173 cells. (A) Heatmap of 80 genes selectively regulated by CDK6 silencing compared with palbociclib treatment in Ph⁺ BV173 cells. (B) Heatmap of 16 genes selectively downregulated or upregulated by CDK6 silencing. (C) Quantitative polymerase chain reaction analysis of selected genes differentially regulated by CDK6 silencing but not palbociclib treatment in Ph⁺ BV173 cells. Data represent mean ± standard deviation of 3 independent experiments. Statistical analysis: one-way analysis of variance with Bonferroni’s correction. *P < .05, **P < .01, ***P < .001. Plots of the correlation between the expression of CDK6 and HDAC1, CDK6 and SMARCD2, and CDK6 and SLC2A3/GLUT3 in a panel of 122 Ph⁺ ALL samples (GSE13159; MILE) (D) and Ph^– B-ALL samples (GSE13159;MILE) (E). n.s., not significant.