Effect of PROTAC YX-2-107 treatment on normal mouse hematopoiesis. Six (2 month-old) C57BL/6j mice were treated with vehicle (Veh) or PROTAC YX-2-107 (107) 150 mg/kg intraperitoneally daily for 10 consecutive days. Four days after cessation of treatment, peripheral blood and bone marrow (BM) cells were collected and analyzed by flow cytometry. (A) Gating strategy for the quantification of stem and progenitor cells. (B) Gating strategy for the quantification of B-lymphoid progenitor cells. (C) Percentage of progenitor populations in the BM. (D) Number of selected hematopoietic cells in the peripheral blood. P value was considered nonsignificant (N.S.) if >.05.