Figure 1.
Severe macrothrombocytopenia in DKO mice is partially rescued in TKO mice. (A) Representative blots of capillary-based immunoassays on platelet lysates with the indicated antibodies. (B) Representative data from panel A displayed as electropherograms. (C) Quantification of peak areas of Csk signal from (A-B), n = 6 mice/genotype. (D) Median fluorescence intensity (MFI) measured in αIIb+ cells costained for PTPRJ in blood, n = 6 mice/genotype. (E) Platelet counts, n = 14 mice/genotype. (F) Platelet volumes, n = 14 mice/genotype. (G) Spleen/body weight ratio, n = 15 mice/genotype. Chk−/− (CKO), Chk−/−;Cskfl/fl;Pf4-Cre+ (DKO), Chk−/−;Cskfl/fl;Ptprjfl/fl;Pf4-Cre+ (TKO). *Significant difference compared with control, or significant difference between DKO and TKO. **P < .01, ***P < .001, 1-way ANOVA with Sidak test; mean ± SD. MW, molecular weight.

Severe macrothrombocytopenia in DKO mice is partially rescued in TKO mice. (A) Representative blots of capillary-based immunoassays on platelet lysates with the indicated antibodies. (B) Representative data from panel A displayed as electropherograms. (C) Quantification of peak areas of Csk signal from (A-B), n = 6 mice/genotype. (D) Median fluorescence intensity (MFI) measured in αIIb+ cells costained for PTPRJ in blood, n = 6 mice/genotype. (E) Platelet counts, n = 14 mice/genotype. (F) Platelet volumes, n = 14 mice/genotype. (G) Spleen/body weight ratio, n = 15 mice/genotype. Chk−/− (CKO), Chk−/−;Cskfl/fl;Pf4-Cre+ (DKO), Chk−/−;Cskfl/fl;Ptprjfl/fl;Pf4-Cre+ (TKO). *Significant difference compared with control, or significant difference between DKO and TKO. **P < .01, ***P < .001, 1-way ANOVA with Sidak test; mean ± SD. MW, molecular weight.

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