Summary of EPAG responses. (A) Bar charts show the absolute numbers and percentage of responders (green shaded) and nonresponders (light blue shaded) for all patients, patients with and without previous IST, and patients with and without germline mutations. (B) Bar charts show the absolute numbers and percentage of responders (color shaded) for patients eligible for an erythroid response, patients eligible for a myeloid response, and patients eligible for bi-lineage responses, both at the primary end point and at best response during the extension study.