Longitudinal follow-up of mutated clone size on and off EPAG. Candidate gene mutations were analyzed at baseline, primary end point, and the latest time point available on and off EPAG. Each panel shows the results in a single patient, with mutated clone size off EPAG (at baseline and long-term follow up) designated by open symbols and clone size on EPAG (at primary end point or during long-term follow-up) designated by closed symbols. Timeline bars designating time on and off EPAG are shown for each patient, with the same color key as used in Figure 2. Specific somatic mutations are listed in supplemental Table 7.