Cutaneous anaplastic large cell lymphoma presenting with multiple skin lesions on the right lower leg. (A) Part disappeared spontaneously. (B) Histologic examination shows a diffuse infiltrate of large anaplastic cells, which are positive for CD30 (C) and show cytoplasmic staining for ALK (D). Staging was negative; initially, an expectant policy was followed. Twelve months after diagnosis, the patient developed systemic disease with involvement of the lungs and bone marrow. Treatment with multiagent chemotherapy was unsuccessful and she died 18 months after diagnosis. Original magnification ×400 (B-D); hematoxylin and eosin (B) and immunoperoxidase (C-D) stain.