BAs in circulation are upregulated during the recovery of pediatric cancer patients. (A-C) PB cellularity in pediatric patients during chemotherapy protocol. Neutrophils (A), monocytes (B), and reticulocytes (C) were monitored during treatment. Samples were collected in the pretreatment, treatment, nadir, recovering, and posttreatment phases (n = 52). (D) TBA levels in patients’ plasma at the different time points. (n = 52). (E-G) Indications of liver damage. ALT (E), GGT (F), and T-Bil (G) are shown (n = 52). (H) Positive correlation of TBA levels between recovering and the nadir (n = 43). (I) Negative correlation between TBA levels at the nadir and recovery time. The recovery time was determined as days from the lowest (bottom phase) neutrophil count to the date when the count exceeded 500 cells per μL (n = 43). Results are presented as means ± SEM. *P < .05; **P < .01; ***P < .001; ****P < .0001. NS, not significant.