BRGS^humanmice show efficient reconstitution of human AML. The kinetics of human CD45⁺CD33⁺ AML cells (patients 1 and 2, top and middle panels) and CD34⁺ AML cells (patient 3; bottom panels) after transplantation into BRGS^human, BRGS^NOD, and NGS mice in the peripheral blood (left panels) and the bone marrow (right panels). The proportions of AML cells in the blood were monitored every 2 weeks, followed by the analysis of bone marrow at the final time point. In all 3 experiments, human AML cell chimerism in BRGS^human mice exceeded that in BRGS^NOD mice. *P < .05, **P < .01. n.s., not significant.