MK-2048 induces caspase-3/7 activation. (A) Caspase-3/7 activity of the indicated cells after 24-hour treatment with MK-2048 (0 to 50 μM). The caspase-3/7 activity values of treated cells relative to those of untreated cells are shown. The results are expressed as the mean ± SD of 3 independent experiments. (B) Simultaneously measured viability. The CellTiter values of treated cells relative to those of untreated cells are shown. The results are expressed as the mean ± SD of 3 independent experiments.