Figure 3.
Impact of rD′D3-FP coadministration on aPTT and thrombin-generation assays in rVIII-SingleChain–treated FVIII-ko mice. The effect of rVIII-SingleChain alone (red lines) or coadministered with rD′D3-FP (blue lines) was assessed as aPTT (A) or in a thrombin-generation assay (B). A vehicle control (gray lines) was tested as negative control. (A) For aPTT, rVIII-SingleChain combined with rD′D3-FP resulted in a reduction of the clotting time even at 96 hours postadministration, whereas rVIII-SingleChain alone resulted in an aPTT similar to that in vehicle-treated animals after 72 hours. (B) Thrombin generation by rVIII-SingleChain in the presence of rD′D3-FP was increased from 48 to 96 hours compared with rVIII-SingleChain alone. Data are mean ± SD of 3 to 10 animals. Dashed lines represent mean vehicle values and dotted lines represent mean ± SD vehicle values.

Impact of rD′D3-FP coadministration on aPTT and thrombin-generation assays in rVIII-SingleChain–treated FVIII-ko mice. The effect of rVIII-SingleChain alone (red lines) or coadministered with rD′D3-FP (blue lines) was assessed as aPTT (A) or in a thrombin-generation assay (B). A vehicle control (gray lines) was tested as negative control. (A) For aPTT, rVIII-SingleChain combined with rD′D3-FP resulted in a reduction of the clotting time even at 96 hours postadministration, whereas rVIII-SingleChain alone resulted in an aPTT similar to that in vehicle-treated animals after 72 hours. (B) Thrombin generation by rVIII-SingleChain in the presence of rD′D3-FP was increased from 48 to 96 hours compared with rVIII-SingleChain alone. Data are mean ± SD of 3 to 10 animals. Dashed lines represent mean vehicle values and dotted lines represent mean ± SD vehicle values.

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