Figure 3.
Hematopoietic populations in NrasG12D,C181S/WTmice. (A) Normal spleen size in NrasG12D,C181S/WT mice (n = 4). (B-C) Immunophenotypic analysis indicating low frequencies of myeloid progenitor cells (B) and differentiated myeloid cells (C) in the spleens of NrasG12D,C181S/WT mice (n = 4). (D-F) Flow-cytometric analysis of the BM of NrasG12D,C181S/WT mice (n = 4) showing normal frequencies of LKS cells (D), myeloid progenitors (E), and differentiated myeloid/lymphoid cells (F). Bar graphs show average values ± SEM. *P < .05; **P < .01; ***P < .001.

Hematopoietic populations in NrasG12D,C181S/WTmice. (A) Normal spleen size in NrasG12D,C181S/WT mice (n = 4). (B-C) Immunophenotypic analysis indicating low frequencies of myeloid progenitor cells (B) and differentiated myeloid cells (C) in the spleens of NrasG12D,C181S/WT mice (n = 4). (D-F) Flow-cytometric analysis of the BM of NrasG12D,C181S/WT mice (n = 4) showing normal frequencies of LKS cells (D), myeloid progenitors (E), and differentiated myeloid/lymphoid cells (F). Bar graphs show average values ± SEM. *P < .05; **P < .01; ***P < .001.

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