Survival in clusters identified by using the Akaike information criterion. (A) OS of the 690 patients treated with curative intent stratified according to cluster. (B) OS of the 579 de novo DLBCL NOS patients treated using R-CHOP, stratified according to cluster. (C) Progression-free survival of the 690 patients treated with curative intent stratified according to cluster. (D) Progression-free survival of the 579 de novo DLBCL NOS patients treated by using R-CHOP, stratified according to cluster. (E) Crude hazard ratios of cluster membership for the 579 de novo DLBCL NOS R-CHOP–treated patients. (F) Adjusted hazard ratios of the subset of the group of 579 patients with IPI data available (n = 499). CI, confidence interval.